Drug Release from Electric-Field-Responsive Nanoparticles
Jun Ge,†,§ Evgenios Neofytou,‡,§ Thomas J. Cahill, III,† Ramin E. Beygui,‡ and Richard N. Zare†,*
†Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States and ‡Department of Cardiothoracic Surgery, Falk Cardiovascular Research
Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5407, United States.§These authors contributed equally to this work.
We describe a new temperature and electric ﬁeld dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric ﬁeld. This approach represents a novel interactive drug delivery system that can show an externally tailored release proﬁle with an excellent spatial, temporal, and dosage control.
KEYWORDS: stimulus-responsive materials . drug delivery . conductive
nanoparticles . polypyrrole . controlled release