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Drug Release from Electric-Field-Responsive Nanoparticles
发布者:admin 发布时间:2012-04-20 23:13:07 阅读:642

     Drug Release from Electric-Field-Responsive Nanoparticles

 

Jun Ge,†,§ Evgenios Neofytou,‡,§ Thomas J. Cahill, III,Ramin E. Beygui,and Richard N. Zare†,*

†Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States and ‡Department of Cardiothoracic Surgery, Falk Cardiovascular Research

Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5407, United States.§These authors contributed equally to this work.

 

 

ABSTRACT

 

  We describe a new temperature and electric eld dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric eld. This approach represents a novel interactive drug delivery system that can show an externally tailored release prole with an excellent spatial, temporal, and dosage control.

 

KEYWORDS:     stimulus-responsive materials . drug delivery . conductive

nanoparticles . polypyrrole . controlled release

 

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